Article
Comprehensive characterization of somatic variants associated with intronic polyadenylation in human cancers.
Nucleic acids research - 11 Oct 2021
Zhao Zhaozhao, Xu Qiushi, Wei Ran, Huang Leihuan, Wang Weixu, Wei Gang, Ni Ting
Abstract excerpt
Somatic single nucleotide variants (SNVs) in cancer genome affect gene expression through various mechanisms depending on their genomic location. While somatic SNVs near canonical splice sites have been reported to cause abnormal splicing of cancer-related genes, whether these SNVs can affect gene expression through other mechanisms remains an open question. Here, we analyzed RNA sequencing and exome data from...
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