Article

Systematic identification of functional SNPs interrupting 3’ UTR polyadenylation signals

2019-09-25

Abstract excerpt

Alternative polyadenylation (APA) is emerging as a widespread regulatory layer as the majority of human protein-coding genes contain several polyadenylation (p(A)) sites in their 3’ UTRs. By generating isoforms with different 3’ UTR length, APA potentially affects mRNA stability, translation efficiency, nuclear export, and cellular localization. Polyadenylation sites are regulated by adjacent RNA cis-regulatory el...

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Literature Corpus work: 796786e6-c682-5439-b501-625decdf044f
DOI: 10.1101/782425

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