Article

Exploring mutational signatures in human cancers using human cell line models

2020-01-01

Abstract excerpt

A cancer genome carries the historic mutagenic activity that has occurred throughout the development of a tumour. While driver mutations were the main focus of cancer research for a long time, passenger mutational signatures – the imprints of DNA damage and DNA repair processes that have been operative during tumourigenesis – are also biologically informative. Since the inception of the field, many mutational sign...

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Literature Corpus work: ef59c6f6-4c6c-5d1a-aced-74ea59fa7536
DOI: 10.17863/cam.48558

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