Article
Understanding mutagenesis through delineation of mutational signatures in human cancer.
Carcinogenesis - 1 Jun 2016
Petljak Mia, Alexandrov Ludmil B
Abstract excerpt
Each individual cell within a human body acquires a certain number of somatic mutations during a course of its lifetime. These mutations originate from a wide spectra of both endogenous and exogenous mutational processes that leave distinct patterns of mutations, termed mutational signatures, embedded within the genomes of all cells. In recent years, the vast amount of data produced by sequencing of cancer...
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