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From Mutational Mechanisms in Single Cells to Mutational Patterns in Cancer Genomes.

Cold Spring Harbor symposia on quantitative biology - 1 Jan 2015

Zhang Cheng-Zhong, Pellman David

Abstract excerpt

Analysis of mutations in thousands of cancer genomes has revealed many characteristic patterns of mutagenesis. The search for the molecular mechanisms underlying these mutational patterns has not only generated novel biological insight but also led to the development of new experimental strategies to study cell-to-cell variation and genome evolution. In this essay, we discuss recent progress in the study of...

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PMID: 26968629
DOI: 10.1101/sqb.2015.80.027623

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