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Article

Experimental systems for the analysis of mutational signatures: no 'one-size-fits-all' solution.

Biochemical Society transactions - 28 Jun 2023

Ivanov Dmitri, Hwang Taejoo, Sitko Lukasz Karol, Lee Semin, Gartner Anton

Abstract excerpt

Cells constantly accumulate mutations, which are caused by replication errors, as well as through the action of endogenous and exogenous DNA-damaging agents. Mutational patterns reflect the status of DNA repair machinery and the history of genotoxin exposure of a given cellular clone. Computationally derived mutational signatures can shed light on the origins of cancer. However, to understand the etiology of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37283472
DOI: 10.1042/BST20221482
PMCID: PMC10317150

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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