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Experimental investigations of carcinogen-induced mutation spectra: Innovation, challenges and future directions.

Mutation research. Genetic toxicology and environmental mutagenesis - 1 May 2020

Melki Pamela N, Korenjak Michael, Zavadil Jiri

Abstract excerpt

Recent years have witnessed an expansion of mutagenesis research focusing on experimentally modeled genome-scale mutational signatures of carcinogens and of endogenous processes. Experimental mutational signatures can explain etiologic links to patterns found in human tumors that may be linked to same exposures, and can serve as biomarkers of exposure history and may even provide insights on causality. A number...

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PMID: 32522347
DOI: 10.1016/j.mrgentox.2020.503195

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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