Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Validating the concept of mutational signatures with isogenic cell models.

Nature communications - 1 May 2018

Zou Xueqing, Owusu Michel, Harris Rebecca, Jackson Stephen P, Loizou Joanna I, Nik-Zainal Serena

Abstract excerpt

The diversity of somatic mutations in human cancers can be decomposed into individual mutational signatures, patterns of mutagenesis that arise because of DNA damage and DNA repair processes that have occurred in cells as they evolved towards malignancy. Correlations between mutational signatures and environmental exposures, enzymatic activities and genetic defects have been described, but human cancers are not...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Algorithms
Share to Cell Line
Share to CRISPR-Cas Systems

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Damage

Share to DNA Repair

Share to Models, Biological

Share to Mutation

Share to Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 29717121
DOI: 10.1038/s41467-018-04052-8
PMCID: PMC5931590

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Validating the concept of mutational signatures with isogenic cell models.PMID 29717121Read ↗

Exploring mutational signatures in human cancers using human cell line modelsSemantic proximity Read ↗

Mechanisms underlying mutational signatures in human cancers.Semantic proximity Read ↗

Understanding mutagenesis through delineation of mutational signatures in human cancer.Semantic proximity Read ↗

Experimental systems for the analysis of mutational signatures: no 'one-size-fits-all' solution.Semantic proximity Read ↗

Mutational signatures: the patterns of somatic mutations hidden in cancer genomes.Semantic proximity Read ↗

The Repertoire of Mutational Signatures in Human CancerSemantic proximity Read ↗

Decomposing the mutational landscape of cancer genomes with RepairSig.Semantic proximity Read ↗

From Mutational Mechanisms in Single Cells to Mutational Patterns in Cancer Genomes.Semantic proximity Read ↗

Experimental investigations of carcinogen-induced mutation spectra: Innovation, challenges and future directions.Semantic proximity Read ↗

Mutational signatures are markers of drug sensitivity of cancer cells.Semantic proximity Read ↗

DNA Repair Footprint Uncovers Contribution of DNA Repair Mechanism to Mutational Signatures.Semantic proximity Read ↗

Dissecting DNA-mismatch-repair-driven mutational processes in human cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.