Article
Mutational signatures are markers of drug sensitivity of cancer cells
2021-05-21
Abstract excerpt
Genomic analyses have revealed mutational signatures that are associated with DNA maintenance gone awry, a common occurrence in tumors. Because cancer therapeutics often target synthesis of DNA building blocks, DNA replication or DNA repair, we hypothesized that mutational signatures would make useful markers of drug sensitivity. We rigorously tested this hypothesis by a global analysis of various drug screening a...
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Identifiers and source
- Literature Corpus work
- 9f8000c5-2180-5e55-a772-750c425d854a
- DOI
- 10.1101/2021.05.19.444811