Article
Base changes in tumour DNA have the power to reveal the causes and evolution of cancer.
Oncogene - 12 Jan 2017
Hollstein M, Alexandrov L B, Wild C P, Ardin M, Zavadil J
Abstract excerpt
Next-generation sequencing (NGS) technology has demonstrated that the cancer genomes are peppered with mutations. Although most somatic tumour mutations are unlikely to have any role in the cancer process per se, the spectra of DNA sequence changes in tumour mutation catalogues have the potential to identify the mutagens, and to reveal the mutagenic processes responsible for human cancer. Very recently, a novel...
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