Article

A genome language model for mapping DNA replication origins

2026-01-30

Abstract excerpt

Origin firing is a central process during DNA replication, but specific sequences defining replication origin usage have not been defined in human cells. Here, we show that a genome language model can accurately predict which sequences can act as an origin of replication, thereby enabling the fast and cost-effective creation of genome-wide replication origin maps. We fine-tuned a genome language model on the prima...

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Literature Corpus work: ef28d75b-b42e-5e24-9476-156145cdfb96
DOI: 10.64898/2026.01.29.702604

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