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Article

Evolution of DNA replication origin specification and gene silencing mechanisms.

Nature communications - 14 Oct 2020

Hu Y, Tareen A, Sheu Y-J, Ireland W T, Speck C, Li H, Joshua-Tor L, Kinney J B, Stillman B

Abstract excerpt

DNA replication in eukaryotic cells initiates from replication origins that bind the Origin Recognition Complex (ORC). Origin establishment requires well-defined DNA sequence motifs in Saccharomyces cerevisiae and some other budding yeasts, but most eukaryotes lack sequence-specific origins. A 3.9 Å structure of S. cerevisiae ORC-Cdc6-Cdt1-Mcm2-7 (OCCM) bound to origin DNA revealed that a loop within Orc2 inserts...

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Share to DNA, Fungal
Share to DNA Replication
Share to Gene Expression Regulation, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Origin Recognition Complex

Share to Protein Conformation, alpha-Helical

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Share to Silent Information Regulator Proteins, Saccharomyces cerevisiae

Source

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Identifiers

PMID: 33056978
DOI: 10.1038/s41467-020-18964-x
PMCID: PMC7560902

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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