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Article

DNA replication initiation shapes the mutational landscape and expression of the human genome.

Science advances - 11 Nov 2022

Murat Pierre, Perez Consuelo, Crisp Alastair, van Eijk Patrick, Reed Simon H, Guilbaud Guillaume, Sale Julian E

Abstract excerpt

The interplay between active biological processes and DNA repair is central to mutagenesis. Here, we show that the ubiquitous process of replication initiation is mutagenic, leaving a specific mutational footprint at thousands of early and efficient replication origins. The observed mutational pattern is consistent with two distinct mechanisms, reflecting the two-step process of origin activation, triggering the...

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Identifiers

PMID: 36351018
DOI: 10.1126/sciadv.add3686
PMCID: PMC9645720

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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