Article

Evolution of Replication Origins in Vertebrate Genomes: Rapid Turnover Despite Selective Constraints

2018-09-10

Abstract excerpt

<h4>Background</h4> The replication programme of vertebrate genomes is driven by the chro-mosomal distribution and timing of activation of tens of thousands of replication origins. Genome-wide studies have shown the frequent association of origins with promoters and CpG islands, and their enrichment in G-quadruplex sequence motifs (G4). However, the genetic determinants driving their activity remain poorly unders...

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Literature Corpus work: bb40616d-8f5a-5219-8295-a7eb454cc794
DOI: 10.1101/411470

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