Article

Using Deep Learning to predict replication timing reveals baseline control of genomic DNA sequence

2026-07-22

Abstract excerpt

Human DNA replicates according to a precise schedule: certain regions are replicated early, while others replicate later in the cell cycle. The DNA sequence and the epigenome are both indicative for replication timing (RT), their relative contributions and potential complementarity yet remain unclear. Here, we utilize Repli-Seq data and machine learning to investigate these relationships in seven human cell lines....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8c975cc1-5e82-513e-a691-4d6d1ecdfdb0
DOI: 10.64898/2026.07.18.739304

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Using Deep Learning to predict replication timing reveals baseline control of genomic DNA sequenceDOI 10.64898/2026.07.18.739304Read

Soffritto: a deep-learning model for predicting high-resolution replication timingSemantic proximity Read

Concert: Genome-wide prediction of sequence elements that modulate DNA replication timingSemantic proximity Read

Latent representation of the human pan-celltype epigenome through a deep recurrent neural networkSemantic proximity Read

A genome language model for mapping DNA replication originsSemantic proximity Read

Learning sequence-based regulatory dynamics in single-cell genomicsSemantic proximity Read

RT States: systematic annotation of the human genome using cell type-specific replication timing programsSemantic proximity Read

Sequencing newly replicated DNA reveals widespread plasticity in human replication timingSemantic proximity Read

DNA replication timing reveals genome-wide features of transcription and fragilitySemantic proximity Read

The Genetic Architecture of DNA Replication Timing in Human Pluripotent Stem CellsSemantic proximity Read

Personalized Morphology, Replication Timing, and RNA based Gene Expression Networks for Basal-like and Classical subtyping genes in Pancreatic AdenocarcinomaSemantic proximity Read

Intrinsic DNA sequence determinants and tissue-specific regulation of human replication originsSemantic proximity Read

Replication Timing Networks: a novel class of gene regulatory networksSemantic proximity Read