Article

Intrinsic DNA sequence determinants and tissue-specific regulation of human replication origins

2025-12-29

Abstract excerpt

The accurate duplication of the genome relies on the spatiotemporal control of DNA replication initiation, yet the determinants specifying mammalian origin locations remain elusive. By developing ORIFormer, a transformer-based neural network, we decode a complex, conserved DNA sequence grammar that accurately predicts initiation sites. This approach uncovers novel determinants, which we validate by demonstrating s...

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Literature Corpus work: 9e4b8c9c-69b5-5d74-80dd-287bac5340bd
DOI: 10.64898/2025.12.28.696672

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