Article

5-hydroxymethylcytosines regulate gene expression as a passive DNA demethylation resisting epigenetic mark in proliferative somatic cells

2023-09-27

Abstract excerpt

<h4>SUMMARY</h4> Enzymatic erasure of DNA methylation in mammals involves iterative 5-methylcytosine (5mC) oxidation by the ten-eleven translocation (TET) family of DNA dioxygenase proteins. As the most abundant form of oxidized 5mC, the prevailing model considers 5-hydroxymethylcytosine (5hmC) as a key nexus in active DNA demethylation that can either indirectly facilitate replication-dependent depletion of 5mC...

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Literature Corpus work: ef12a793-14f6-5c53-9558-0257f6e2c0cd
DOI: 10.1101/2023.09.26.559662

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