Article

Epigenetic reprogramming by TET enzymes impacts co-transcriptional R-loops

2021-04-27

Abstract excerpt

DNA oxidation by ten-eleven translocation (TET) family enzymes is essential for epigenetic reprogramming. The conversion of 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) initiates developmental and cell-type-specific transcriptional programs through mechanisms that include changes in the chromatin structure. Here, we show that the presence of 5hmC in the transcribed DNA promotes the annealing of the n...

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Literature Corpus work: 3a617ab0-2899-5b0f-a8a6-e623e525f2ab
DOI: 10.1101/2021.04.26.441414

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