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Article

Functionally distinct roles for TET-oxidized 5-methylcytosine bases in somatic reprogramming to pluripotency.

Molecular cell - 18 Feb 2021

Caldwell Blake A, Liu Monica Yun, Prasasya Rexxi D, Wang Tong, DeNizio Jamie E, Leu N Adrian, Amoh Nana Yaa A, Krapp Christopher, Lan Yemin, Shields Emily J, Bonasio Roberto, Lengner Christopher J, Kohli Rahul M, Bartolomei Marisa S

Abstract excerpt

Active DNA demethylation via ten-eleven translocation (TET) family enzymes is essential for epigenetic reprogramming in cell state transitions. TET enzymes catalyze up to three successive oxidations of 5-methylcytosine (5mC), generating 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), or 5-carboxycytosine (5caC). Although these bases are known to contribute to distinct demethylation pathways, the lack of...

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Identifiers

PMID: 33352108
DOI: 10.1016/j.molcel.2020.11.045
PMCID: PMC7897302

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