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Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine

14 Feb 2011

Abstract excerpt

Genome-wide erasure of DNA cytosine-5 methylation has been reported to occur along the paternal pronucleus in fertilized oocytes in an apparently replication-independent manner, but the mechanism of this reprogramming process has remained enigmatic. Recently, considerable amounts of 5-hydroxymethylcytosine (5hmC), most likely derived from enzymatic oxidation of 5-methylcytosine (5mC) by TET proteins, have been...

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PMID: 21321204
DOI: 10.1073/pnas.1014033108

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