Article

TET1 Catalytic Activity is Required for Reprogramming of Imprinting Control Regions and Patterning of Sperm-Specific Hypomethylated Regions

2023-02-21

Abstract excerpt

<h4>SUMMARY</h4> DNA methylation erasure is required for mammalian primordial germ cell reprogramming. TET enzymes iteratively oxidize 5-methylcytosine to generate 5-hyroxymethylcytosine (5hmC), 5-formylcytosine, and 5-carboxycytosine to facilitate active genome demethylation. Whether these bases are required to promote replication-coupled dilution or activate base excision repair during germline reprogramming re...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cc2330d4-55c1-5150-a021-438026824ca1
DOI: 10.1101/2023.02.21.529426

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TET1 Catalytic Activity is Required for Reprogramming of Imprinting Control Regions and Patterning of Sperm-Specific Hypomethylated RegionsDOI 10.1101/2023.02.21.529426Read

5-hydroxymethylcytosines regulate gene expression as a passive DNA demethylation resisting epigenetic mark in proliferative somatic cellsSemantic proximity Read

Iterative oxidation by TET1 is required for reprogramming of imprinting control regions and patterning of mouse sperm hypomethylated regionsSemantic proximity Read

Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosineSemantic proximity Read

Role of Tet1 in erasure of genomic imprinting.Semantic proximity Read

Functionally distinct roles for TET-oxidized 5-methylcytosine bases in somatic reprogramming to pluripotency.Semantic proximity Read

DNA methylation and DNA methyltransferases.Semantic proximity Read

Joint profiling of 5mC, 5hmC, and the transcriptome in single cells identifies factors responsible for genome-wide DNA methylation erasure in human primordial germ cell maturationSemantic proximity Read

Rescuing DNMT1 Fails to Fully Reverse the Molecular and Functional Repercussions of Its Loss in Mouse Embryonic Stem CellsSemantic proximity Read

Genome-Wide Reprogramming in the Mouse Germ Line Entails the Base Excision Repair PathwaySemantic proximity Read

OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wideSemantic proximity Read

Maternal TET3 is dispensable for embryonic development but is required for neonatal growthSemantic proximity Read

Spatiotemporal DNA Methylome Dynamics of the Developing Mammalian FetusSemantic proximity Read