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Article

5-Methylcytosine DNA demethylation: more than losing a methyl group.

Annual review of genetics - 1 Jan 2012

Franchini Don-Marc, Schmitz Kerstin-Maike, Petersen-Mahrt Svend K

Abstract excerpt

Demethylation of 5-methylcytosine in DNA is integral to the maintenance of an intact epigenome. The balance between the presence or absence of 5-methylcytosine determines many physiological aspects of cell metabolism, with a turnover that can be measured in minutes to years. Biochemically, addition of the methyl group is shared among all living kingdoms and has been well characterized, whereas the removal or...

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PMID: 22974304
DOI: 10.1146/annurev-genet-110711-155451

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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