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Article

Mutations along a TET2 active site scaffold stall oxidation at 5-hydroxymethylcytosine.

Nature chemical biology - 1 Feb 2017

Liu Monica Yun, Torabifard Hedieh, Crawford Daniel J, DeNizio Jamie E, Cao Xing-Jun, Garcia Benjamin A, Cisneros G Andrés, Kohli Rahul M

Abstract excerpt

Ten-eleven translocation (TET) enzymes catalyze stepwise oxidation of 5-methylcytosine (mC) to yield 5-hydroxymethylcytosine (hmC) and the rarer bases 5-formylcytosine (fC) and 5-carboxylcytosine (caC). Stepwise oxidation obscures how each individual base forms and functions in epigenetic regulation, and prompts the question of whether TET enzymes primarily serve to generate hmC or are adapted to produce fC and...

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Identifiers

PMID: 27918559
DOI: 10.1038/nchembio.2250
PMCID: PMC5370579

Genes

TET2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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