Article

Structural mechanism for bi-directional actin crosslinking by T-plastin

2021-12-09

Abstract excerpt

To fulfill the cytoskeleton’s diverse functions in cell mechanics and motility, actin networks with specialized architectures are built by crosslinking proteins, which bridge filaments to control micron-scale network geometry through nanoscale binding interactions via poorly defined structural mechanisms. Here, we introduce a machine-learning enabled cryo-EM pipeline for visualizing active crosslinkers, which we u...

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Literature Corpus work: eef2b209-79d0-559e-8b27-f7a78cc1972f
DOI: 10.1101/2021.12.07.471696

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