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Article

Modeling the assembly of the multiple domains of α-actinin-4 and its role in actin cross-linking.

Biophysical journal - 5 Feb 2013

Travers Timothy, Shao Hanshuang, Wells Alan, Camacho Carlos J

Abstract excerpt

The assembly of proteins into multidomain complexes is critical for their function. In eukaryotic nonmuscle cells, regulation of the homodimeric actin cross-linking protein α-actinin-4 (ACTN4) during cell migration involves signaling receptors with intrinsic tyrosine kinase activity, yet the underlying molecular mechanisms are poorly understood. As a first step to address the latter, we validate here an atomic...

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Identifiers

PMID: 23442921
DOI: 10.1016/j.bpj.2012.12.003
PMCID: PMC3566466

Genes

ACTN4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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