Back to search

Article

Myosin forces elicit an F-actin structural landscape that mediates mechanosensitive protein recognition

2024-08-17

Abstract excerpt

Cells mechanically interface with their surroundings through cytoskeleton-linked adhesions, allowing them to sense physical cues that instruct development and drive diseases such as cancer. Contractile forces generated by myosin motor proteins mediate these mechanical signal transduction processes through unclear protein structural mechanisms. Here, we show that myosin forces elicit structural changes in actin fil...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
6d50e5bc-baf0-5028-8618-4dd514a25c3e
DOI
10.1101/2024.08.15.608188
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Myosin forces elicit an F-actin structural landscape that mediates mechanosensitive protein recognitionDOI 10.1101/2024.08.15.608188
Force-modulated structural landscape of the catch bonding F-actin crosslinker α-actinin-4Semantic proximity
Actomyosin clusters as active units shaping living matterSemantic proximity
Actin force generation in vesicle formation: mechanistic insights from cryo-electron tomographySemantic proximity
DOCK8 regulates a mechanosensitive actin redistribution that maintains immune cell cohesion and protects the nucleus during migrationSemantic proximity
The molecular basis for sarcomere organization in vertebrate skeletal muscleSemantic proximity
The force-sensing device region of α-catenin is an intrinsically disordered segment in the absence of intramolecular stabilization of the autoinhibitory form.Semantic proximity
Structure of the F-actin-tropomyosin complex.Semantic proximity
A Focal Adhesion Filament Cross-correlation Kit for fast, automated segmentation and correlation of focal adhesions and actin stress fibers in cellsSemantic proximity
ATP allosterically stabilizes Integrin-linked kinase for efficient force generationSemantic proximity
Molecular plasticity of the native mouse skeletal sarcomere revealed by cryo-ETSemantic proximity
Molecular mechanism of actin filament elongation by formins.Semantic proximity
Cadherin mechanotransduction in tissue remodeling.Semantic proximity
Select a neighboring publication to make it the new centre.