Article

Human plastins are novel cytoskeletal pH sensors with a reduced F-actin bundling capacity at basic pH

2025-03-28

Abstract excerpt

Intracellular pH (pH i ) is a fundamental component of cell homeostasis. Controlled elevations in pH i precede and accompany cell polarization, cytokinesis, and directional migration. pH dysregulation contributes to cancer, neurodegenerative diseases, diabetes, and other metabolic disorders. While cytoskeletal rearrangements are crucial for these processes, only a few cytoskeletal proteins, namely Cdc42, cofilin...

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Literature Corpus work: 447d2e3b-a48d-5d68-bbbd-56cc5ce6574c
DOI: 10.1101/2025.03.26.645573

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