Article

Force-modulated structural landscape of the catch bonding F-actin crosslinker α-actinin-4

2026-03-06

Abstract excerpt

Catch bonds, noncovalent supramolecular interactions whose lifetimes are increased by force, are ubiquitous in mechanical signaling pathways. The structural mechanisms of catch-bonding proteins remain unclear, hampering efforts to decipher how they are dysregulated in disease and exploit them therapeutically. The crosslinker α-actinin-4 (ACTN4) forms catch bonds with actin filaments (F-actin) to support the functi...

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Literature Corpus work: 54a8a70b-4acd-55a6-907a-64ba050d30ca
DOI: 10.64898/2026.03.04.709699

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