Article

Cryo-EM Reveals the Mechanochemical Cycle of Reactive Full-length Human Dynein-1

2024-05-01

Abstract excerpt

Dynein-driven cargo transport plays pivotal roles in diverse cellular activities, central to which is dynein’s mechanochemical cycle. Here, we performed a systematic cryo-electron microscopic investigation of the conformational landscape of full-length human dynein-1 in reaction, under various nucleotide conditions, on and off microtubules. Our approach reveals over 40 high-resolution structures, categorized into...

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Literature Corpus work: 17aebf2f-3a1a-51fe-8a9c-2439efa40733
DOI: 10.1101/2024.05.01.592044

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