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Article

The molecular basis for sarcomere organization in vertebrate skeletal muscle

24 Mar 2021

Abstract excerpt

Sarcomeres are force-generating and load-bearing devices of muscles. A precise molecular picture of how sarcomeres are built underpins understanding their role in health and disease. Here, we determine the molecular architecture of native vertebrate skeletal sarcomeres by electron cryo-tomography. Our reconstruction reveals molecular details of the three-dimensional organization and interaction of actin and...

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PMID: 33765442
DOI: 10.1016/j.cell.2021.02.047

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