Article

Cryo-EM structure of the human cardiac myosin filament

2023-04-12

Abstract excerpt

<h4> Abstract </h4> Pumping of the heart is powered by filaments of the motor protein myosin, which pull on actin filaments to generate cardiac contraction. In addition to myosin, the filaments contain cardiac myosin-binding protein C (cMyBP-C), which modulates contractility in response to physiological stimuli, and titin, which functions as a scaffold for filament assembly 1 . Myosin, cMyBP-C and titin are all...

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Literature Corpus work: 8eac27d6-2eaf-5494-83f5-69143fa9b394
DOI: 10.1101/2023.04.11.536274

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