Back to search

Article

Molecular plasticity of the native mouse skeletal sarcomere revealed by cryo-ET

2020-09-13

Abstract excerpt

Sarcomeres are the force-generating and load-bearing devices of muscles. A precise molecular understanding of how the entire sarcomere is built is required to understand its role in health, disease and ageing. Here, we determine the in situ molecular architecture of vertebrate skeletal sarcomeres through electron cryo-tomography of cryo-focused ion beam-milled native myofibrils. The reconstructions reveal the thr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
47498e55-cd92-5783-8979-362f3e15cc09
DOI
10.1101/2020.09.13.295386
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Molecular plasticity of the native mouse skeletal sarcomere revealed by cryo-ETDOI 10.1101/2020.09.13.295386
The molecular basis for sarcomere organization in vertebrate skeletal muscleSemantic proximity
Structures from intact myofibrils reveal mechanism of thin filament regulation through nebulin.Semantic proximity
In situ structures from relaxed cardiac myofibrils reveal the organization of the muscle thick filamentSemantic proximity
Structure of the Thin Filament in Human iPSC-derived Cardiomyocytes and its Response to Heart DiseaseSemantic proximity
Structure of the F-actin-tropomyosin complex.Semantic proximity
High-Resolution Cryo-EM Structure of the Cardiac Actomyosin Complex.Semantic proximity
Cryo-EM structure of the human cardiac myosin filamentSemantic proximity
Cryo-ET reveals nanoscale thick filament disorganization in MYH7 P710R hypertrophic cardiomyopathy cardiomyocytesSemantic proximity
Sorting of a nonmuscle tropomyosin to a novel cytoskeletal compartment in skeletal muscle results in muscular dystrophy.Semantic proximity
The molecular architecture of vimentin filamentsSemantic proximity
Myosin forces elicit an F-actin structural landscape that mediates mechanosensitive protein recognitionSemantic proximity
In situ cryo-electron tomography reveals the asymmetric architecture of mammalian sperm axonemesSemantic proximity
Select a neighboring publication to make it the new centre.