Article
D-loop Dynamics and Near-Atomic-Resolution Cryo-EM Structure of Phalloidin-Bound F-Actin.
Structure (London, England : 1993) - 5 May 2020
Das Sanchaita, Ge Peng, Oztug Durer Zeynep A, Grintsevich Elena E, Zhou Z Hong, Reisler Emil
Abstract excerpt
Detailed molecular information on G-actin assembly into filaments (F-actin), and their structure, dynamics, and interactions, is essential for understanding their cellular functions. Previous studies indicate that a flexible DNase I binding loop (D-loop, residues 40-50) plays a major role in actin's conformational dynamics. Phalloidin, a "gold standard" for actin filament staining, stabilizes them and affects the...
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