Article

Identification of CDRH3 Loops in the B Cell Receptor Repertoire that Can Be Engaged by Candidate Immunogens

2021-12-19

Abstract excerpt

A major goal for the development of vaccines against rapidly mutating viruses, such as influenza or HIV, is to elicit antibodies with broad neutralization capacity. However, B cell precursors capable of maturing into broadly neutralizing antibodies (bnAbs) can be rare in the immune repertoire. Due to the stochastic nature of B cell receptor (BCR) rearrangement, a limited number of third heavy chain complementary d...

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Literature Corpus work: eebc5528-81e2-57a9-954a-08f4f6d24ce4
DOI: 10.1101/2021.12.18.473225

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