Article
HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen.
Science (New York, N.Y.) - 25 Mar 2016
Jardine Joseph G, Kulp Daniel W, Havenar-Daughton Colin, Sarkar Anita, Briney Bryan, Sok Devin, Sesterhenn Fabian, Ereño-Orbea June, Kalyuzhniy Oleksandr, Deresa Isaiah, Hu Xiaozhen, Spencer Skye, Jones Meaghan, Georgeson Erik, Adachi Yumiko, Kubitz Michael, deCamp Allan C, Julien Jean-Philippe, Wilson Ian A, Burton Dennis R, Crotty Shane, Schief William R
Abstract excerpt
Induction of broadly neutralizing antibodies (bnAbs) is a major HIV vaccine goal. Germline-targeting immunogens aim to initiate bnAb induction by activating bnAb germline precursor B cells. Critical unmet challenges are to determine whether bnAb precursor naïve B cells bind germline-targeting immunogens and occur at sufficient frequency in humans for reliable vaccine responses. Using deep mutational scanning and...
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