An engineered immunogen activates diverse HIV broadly neutralizing antibody precursors and promotes acquisition of improbable mutations.

doi:10.1126/scitranslmed.adr2218

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

An engineered immunogen activates diverse HIV broadly neutralizing antibody precursors and promotes acquisition of improbable mutations.

Science translational medicine - 8 Jan 2025

Swanson Olivia M, Zhang Qianyi E, Van Itallie Elizabeth, Tian Ming, Brown Alecia R, Harris Caitlin, Kapingidza Anyway Brenda, Rhodes Brianna, Smith Lena M, Venkatayogi Sravani, Cronin Kenneth, Frazier McKenzie, Parks Rob, Bar Maggie, Jiang Chuancang, Martin Beem Joshua S, Cheng Hwei-Ling, Davis Jillian, McGovern Kelly, Newman Amanda, Edwards Robert J, Cain Derek, Alam S Munir, Wiehe Kevin, Saunders Kevin O, Acharya Priyamvada, Alt Fred, Haynes Barton F, Azoitei Mihai L

Abstract excerpt

Elicitation of HIV broadly neutralizing antibodies (bnAbs) by vaccination first requires the activation of diverse precursors, followed by successive boosts that guide these responses to enhanced breadth through the acquisition of somatic mutations. Because HIV bnAbs contain mutations in their B cell receptors (BCRs) that are rarely generated during conventional B cell maturation, HIV vaccine immunogens must...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AIDS Vaccines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antibodies, Neutralizing

Share to B-Lymphocytes

Share to HIV-1

Share to HIV Antibodies

Share to HIV Infections

Share to Mice

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 39772772
DOI: 10.1126/scitranslmed.adr2218
PMCID: PMC13419659

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An engineered immunogen activates diverse HIV broadly neutralizing antibody precursors and promotes acquisition of improbable mutations.PMID 39772772Read ↗

Rapid selection of HIV envelopes that bind to neutralizing antibody B cell lineage members with functional improbable mutations.Semantic proximity Read ↗

Mutation-guided vaccine design: A process for developing boosting immunogens for HIV broadly neutralizing antibody induction.Semantic proximity Read ↗

Rapid selection of HIV envelopes that bind to neutralizing antibody B cell lineage members with functional improbable mutationsSemantic proximity Read ↗

HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen.Semantic proximity Read ↗

Functional Relevance of Improbable Antibody Mutations for HIV Broadly Neutralizing Antibody Development.Semantic proximity Read ↗

Functional Improbable Antibody Mutations Critical for HIV Broadly Neutralizing Antibody DevelopmentSemantic proximity Read ↗

Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design.Semantic proximity Read ↗

Consistent Induction of Broadly Neutralizing HIV Antibodies by a Novel Two-Step Mechanism Informs Immunogen DesignSemantic proximity Read ↗

Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies.Semantic proximity Read ↗

Vaccination induces maturation in a mouse model of diverse unmutated VRC01-class precursors to HIV-neutralizing antibodies with >50% breadth.Semantic proximity Read ↗

HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies.Semantic proximity Read ↗

Engineering immunogens that select for specific mutations in HIV broadly neutralizing antibodies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.