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Article

Rapid selection of HIV envelopes that bind to neutralizing antibody B cell lineage members with functional improbable mutations.

Cell reports - 17 Aug 2021

Swanson Olivia, Rhodes Brianna, Wang Avivah, Xia Shi-Mao, Parks Robert, Chen Haiyan, Sanzone Aja, Cooper Melissa, Louder Mark K, Lin Bob C, Doria-Rose Nicole A, Bonsignori Mattia, Saunders Kevin O, Wiehe Kevin, Haynes Barton F, Azoitei Mihai L

Abstract excerpt

Elicitation of broadly neutralizing antibodies (bnAbs) by an HIV vaccine will involve priming the immune system to activate antibody precursors, followed by boosting immunizations to select for antibodies with functional features required for neutralization breadth. The higher the number of acquired mutations necessary for function, the more convoluted are the antibody developmental pathways. HIV bnAbs acquire a...

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Share to Antibodies, Neutralizing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to env Gene Products, Human Immunodeficiency Virus

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Identifiers

PMID: 34407396
DOI: 10.1016/j.celrep.2021.109561
PMCID: PMC8493474

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