Engineering immunogens that select for specific mutations in HIV broadly neutralizing antibodies.

doi:10.1038/s41467-024-53120-9

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Article

Engineering immunogens that select for specific mutations in HIV broadly neutralizing antibodies.

Nature communications - 3 Nov 2024

Henderson Rory, Anasti Kara, Manne Kartik, Stalls Victoria, Saunders Carrie, Bililign Yishak, Williams Ashliegh, Bubphamala Pimthada, Montani Maya, Kachhap Sangita, Li Jingjing, Jaing Chuancang, Newman Amanda, Cain Derek W, Lu Xiaozhi, Venkatayogi Sravani, Berry Madison, Wagh Kshitij, Korber Bette, Saunders Kevin O, Tian Ming, Alt Fred, Wiehe Kevin, Acharya Priyamvada, Alam S Munir, Haynes Barton F

Abstract excerpt

Vaccine development targeting rapidly evolving pathogens such as HIV-1 requires induction of broadly neutralizing antibodies (bnAbs) with conserved paratopes and mutations, and in some cases, the same Ig-heavy chains. The current trial-and-error search for immunogen modifications that improve selection for specific bnAb mutations is imprecise. Here, to precisely engineer bnAb boosting immunogens, we use molecular...

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Identifiers

PMID: 39489734
DOI: 10.1038/s41467-024-53120-9
PMCID: PMC11532496

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