Article
Differences in Allelic Frequency and CDRH3 Region Limit the Engagement of HIV Env Immunogens by Putative VRC01 Neutralizing Antibody Precursors.
Cell reports - 1 Nov 2016
Yacoob Christina, Pancera Marie, Vigdorovich Vladimir, Oliver Brian G, Glenn Jolene A, Feng Junli, Sather D Noah, McGuire Andrew T, Stamatatos Leonidas
Abstract excerpt
Elicitation of broadly neutralizing antibodies remains a long-standing goal of HIV vaccine research. Although such antibodies can arise during HIV-1 infection, gaps in our knowledge of their germline, pre-immune precursor forms, as well as on their interaction with viral Env, limit our ability to elicit them through vaccination. Studies of broadly neutralizing antibodies from the VRC01-class provide insight into...
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