Article
Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization.
Cell - 28 Mar 2013
Klein Florian, Diskin Ron, Scheid Johannes F, Gaebler Christian, Mouquet Hugo, Georgiev Ivelin S, Pancera Marie, Zhou Tongqing, Incesu Reha-Baris, Fu Brooks Zhongzheng, Gnanapragasam Priyanthi N P, Oliveira Thiago Y, Seaman Michael S, Kwong Peter D, Bjorkman Pamela J, Nussenzweig Michel C
Abstract excerpt
Broadly neutralizing antibodies (bNAbs) to HIV-1 can prevent infection and are therefore of great importance for HIV-1 vaccine design. Notably, bNAbs are highly somatically mutated and generated by a fraction of HIV-1-infected individuals several years after infection. Antibodies typically accumulate mutations in the complementarity determining region (CDR) loops, which usually contact the antigen. The CDR loops...
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