Article
Deep mining of the human antibody repertoire identifies frequent and genetically diverse CDRH3 topologies targetable by vaccination.
Proceedings of the National Academy of Sciences of the United States of America - 5 May 2026
Habib Rumi, Solieva Shahlo O, Lin Zi Jie, Ghosh Sukanya, Bayruns Kelly, Singh Maya, Agostino Colby J, Tursi Nicholas J, Sowers Kirsten J, Huang Jinwei, Roark Ryan S, Purwar Mansi, Park Younghoon, Ayyanathan Kasirajan, Li Hui, Carey John W, Kim Amber, Park Joyce, McCanna Madison E, Skelly Ashwin N, Chokkalingam Neethu, Kriete Sinja, Shupin Nicholas, Huynh Alana, Walker Susanne, Sadeesh Roopak, Laenger Niklas, Du Jianqiu, Cui Jiayan, Patel Ami, Escolano Amelia, Kwong Peter D, Shapiro Lawrence, Bowman Gregory R, Hahn Beatrice H, Shaw George M, Weiner David B, Pallesen Jesper, Kulp Daniel W
Abstract excerpt
Germline targeting vaccination strategies against highly variable pathogens such as HIV aim to elicit broadly neutralizing antibodies (bnAbs) with particular immunogenetic or structural features. The V2 apex of the HIV Env protein is a promising target for a class of bnAbs that contain conserved structural motifs in the heavy chain complementarity determining region 3 (CDRH3). Here, we show that these structural...
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