Article

Mapping essential somatic hypermutations in a CD4-binding site bNAb informs HIV-1 vaccine design

2024-11-29

Abstract excerpt

<h4>Summary</h4> HIV-1 broadly-neutralizing antibodies (bNAbs) targeting the CD4-binding site (CD4bs) contain rare features that pose challenges to elicit these bNAbs through vaccination. The IOMA-class of CD4bs bNAbs includes fewer rare features and somatic hypermutations (SHMs) to achieve broad neutralization, thus presenting a potentially accessible pathway for vaccine-induced bNAb development. Here, we create...

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Literature Corpus work: beda945d-26ef-5034-8fe5-4ba78fd5347f
DOI: 10.1101/2024.11.26.625503

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