Article
Mapping essential somatic hypermutations in a CD4-binding site bNAb informs HIV-1 vaccine design.
Cell reports - 27 May 2025
Dam Kim-Marie A, Gristick Harry B, Li Yancheng E, Yang Zhi, Gnanapragasam Priyanthi N P, West Anthony P, Seaman Michael S, Bjorkman Pamela J
Abstract excerpt
HIV-1 broadly neutralizing antibodies (bNAbs) targeting the CD4-binding site (CD4bs) contain rare features that pose challenges to elicit these bNAbs through vaccination. The IOMA class of CD4bs bNAbs includes fewer rare features and somatic hypermutations (SHMs) to achieve broad neutralization, thus presenting a potentially accessible pathway for vaccine-induced bNAb development. Here, we created a library of...
Topics
- AIDS Vaccines
- HIV-1
- Humans
- Antibodies, Neutralizing
- Binding Sites
- HIV Antibodies
- CD4 Antigens
- Mutation
- Cryoelectron Microscopy