Article

Deep Mining of the Human Antibody Repertoire Identifies Frequent and Genetically Diverse CDRH3 Topologies Targetable by Vaccination

2024-10-05

Abstract excerpt

Germline targeting vaccination strategies against highly variable pathogens such as HIV aim to elicit broadly neutralizing antibodies (bnAbs) with particular immunogenetic or structural features. The V2 apex of the HIV Env protein is a promising target for a class of bnAbs that contain conserved structural motifs in the heavy chain complementarity determining region 3 (CDRH3). Here, we show that these structural m...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d3b5dd0d-fcef-5e4e-8d60-d62847f75e0d
DOI: 10.1101/2024.10.04.616739

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Deep Mining of the Human Antibody Repertoire Identifies Frequent and Genetically Diverse CDRH3 Topologies Targetable by VaccinationDOI 10.1101/2024.10.04.616739Read

Deep mining of the human antibody repertoire identifies frequent and genetically diverse CDRH3 topologies targetable by vaccination.Semantic proximity Read

Human immunoglobulin repertoire analysis guides design of vaccine priming immunogens targeting HIV V2-apex broadly neutralizing antibody precursorsSemantic proximity Read

Identification of CDRH3 Loops in the B Cell Receptor Repertoire that Can Be Engaged by Candidate ImmunogensSemantic proximity Read

Differences in Allelic Frequency and CDRH3 Region Limit the Engagement of HIV Env Immunogens by Putative VRC01 Neutralizing Antibody Precursors.Semantic proximity Read

Structural and genetic basis of HIV-1 envelope V2 apex recognition by rhesus broadly neutralizing antibodiesSemantic proximity Read

Convergent Sequence Features of Antiviral B CellsSemantic proximity Read

Large-scale sequence and structural comparisons of human naive and antigen-experienced antibody repertoiresSemantic proximity Read

Rapid vaccine induction of macaque HIV-1 V2 Apex broadly neutralizing antibodies with immunogenetic signatures that are potentially translatable to humansSemantic proximity Read

Antibody sequence determinants of viral antigen specificitySemantic proximity Read

Mining the antibodyome for HIV-1–neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chainsSemantic proximity Read

High-Resolution Description of Antibody Heavy-Chain Repertoires in HumansSemantic proximity Read

High-Throughput B Cell Epitope Determination by Next-Generation SequencingSemantic proximity Read