Article

Structural and functional studies of the RBPJ-SHARP complex reveal conserved corepressor binding site

2018-05-09

Abstract excerpt

The Notch pathway is a conserved signaling mechanism that is essential for cell fate decisions during pre and postnatal development. Dysregulated signaling underlies the pathophysiology of numerous human diseases, most notably T-cell acute lymphoblastic leukemia. Receptor-ligand interactions result in changes in gene expression, which are regulated by the transcription factor CSL. CSL forms a complex with the intr...

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Literature Corpus work: eeaceb19-5efb-55ca-bda5-b9e032cf9754
DOI: 10.1101/273615

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