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Article

OPTHiS Identifies the Molecular Basis of the Direct Interaction between CSL and SMRT Corepressor.

Molecules and cells - 30 Sept 2018

Kim Gwang Sik, Park Hee-Sae, Lee Young Chul

Abstract excerpt

Notch signaling is an evolutionarily conserved pathway and involves in the regulation of various cellular and developmental processes. Ligand binding releases the intracellular domain of Notch receptor (NICD), which interacts with DNA-bound CSL [CBF1/Su(H)/Lag-1] to activate transcription of target genes. In the absence of NICD binding, CSL down-regulates target gene expression through the recruitment of various...

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Identifiers

PMID: 30157580
DOI: 10.14348/molcells.2018.0196
PMCID: PMC6182220

Genes

BTD
HDAC1

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OPTHiS Identifies the Molecular Basis of the Direct Interaction between CSL and SMRT Corepressor.PMID 30157580Read ↗

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