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Article

Structure and function of the CSL-KyoT2 corepressor complex: a negative regulator of Notch signaling.

Structure (London, England : 1993) - 7 Jan 2014

Collins Kelly J, Yuan Zhenyu, Kovall Rhett A

Abstract excerpt

Notch refers to a highly conserved cell-to-cell signaling pathway with essential roles in embryonic development and tissue maintenance. Dysfunctional signaling causes human disease, highlighting the importance of pathway regulation. Notch signaling ultimately results in the activation of target genes, which is regulated by the nuclear effector CSL (CBF-1/RBP-J, Su(H), Lag-1). CSL dually functions as an activator...

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Identifiers

PMID: 24290140
DOI: 10.1016/j.str.2013.10.010
PMCID: PMC3947186

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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