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Article

Characterization of CSL (CBF-1, Su(H), Lag-1) mutants reveals differences in signaling mediated by Notch1 and Notch2.

The Journal of biological chemistry - 12 Oct 2012

Yuan Zhenyu, Friedmann David R, VanderWielen Bradley D, Collins Kelly J, Kovall Rhett A

Abstract excerpt

Notch is a conserved signaling pathway that plays essential roles during embryonic development and postnatally in adult tissues; misregulated signaling results in human disease. Notch receptor-ligand interactions trigger cleavage of the Notch receptor and release of its intracellular domain (NICD) from the membrane. NICD localizes to the nucleus where it forms a transcriptionally active complex with the...

Topics

Animals
DNA-Binding Proteins
Humans
Immunoglobulin J Recombination Signal Sequence-Binding Protein
Mice
Mice, Knockout
Mutation
Receptor, Notch1
Receptor, Notch2
Signal Transduction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transcription Factors

Transcription, Genetic

Up-Regulation

Source

Open in PubMed Open full text

Identifiers

PMID: 22915591
DOI: 10.1074/jbc.M112.403287
PMCID: PMC3471696

Genes

CBS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Click a neighbor to travelStep 1 · 12 closest

Characterization of CSL (CBF-1, Su(H), Lag-1) mutants reveals differences in signaling mediated by Notch1 and Notch2.PMID 22915591Read ↗

Structure and function of the CSL-KyoT2 corepressor complex: a negative regulator of Notch signaling.Semantic proximity Read ↗

Evidence that C promoter-binding factor 1 binding is required for Notch-1-mediated repression of activator protein-1.Semantic proximity Read ↗

The structure, binding, and function of a Notch transcription complex involving RBPJ and the epigenetic reader protein L3MBTL3Semantic proximity Read ↗

Structural and functional studies of the RBPJ-SHARP complex reveal conserved corepressor binding siteSemantic proximity Read ↗

MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.Semantic proximity Read ↗

OPTHiS Identifies the Molecular Basis of the Direct Interaction between CSL and SMRT Corepressor.Semantic proximity Read ↗

Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1.Semantic proximity Read ↗

The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesis.Semantic proximity Read ↗

Identification of a Paralog-Specific Notch1 Intracellular Domain Degron.Semantic proximity Read ↗

Investigating the genetic circuitry of mastermind in Drosophila, a notch signal effector.Semantic proximity Read ↗

Characterization of a new mastermind allele identified from somatic mosaic screen.Semantic proximity Read ↗

Hairless-binding deficient Suppressor of Hairless alleles reveal Su(H) protein levels are dependent on complex formation with Hairless.Semantic proximity Read ↗

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