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Article

Structure-function analysis of RBP-J-interacting and tubulin-associated (RITA) reveals regions critical for repression of Notch target genes.

The Journal of biological chemistry - 23 Jun 2017

Tabaja Nassif, Yuan Zhenyu, Oswald Franz, Kovall Rhett A

Abstract excerpt

The Notch pathway is a cell-to-cell signaling mechanism that is essential for tissue development and maintenance, and aberrant Notch signaling has been implicated in various cancers, congenital defects, and cardiovascular diseases. Notch signaling activates the expression of target genes, which are regulated by the transcription factor CSL (CBF1/RBP-J, Su(H), Lag-1). CSL interacts with both transcriptional...

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PMID: 28487372
DOI: 10.1074/jbc.M117.791707
PMCID: PMC5481562

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