Article
Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1.
Molecular and cellular biology - 1 Aug 2006
Chiang Mark Y, Xu Mina L, Histen Gavin, Shestova Olga, Roy Monideepa, Nam Yunsun, Blacklow Stephen C, Sacks David B, Pear Warren S, Aster Jon C
Abstract excerpt
NOTCH1 is a large type I transmembrane receptor that regulates normal T-cell development via a signaling pathway that relies on regulated proteolysis. Ligand binding induces proteolytic cleavages in NOTCH1 that release its intracellular domain (ICN1), which translocates to the nucleus and activates target genes by forming a short-lived nuclear complex with two other proteins, the DNA-binding factor CSL and a...
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